CAS No.: 952021-60-2
(R)-2-Amino-2-cyclohexyl-N-(5-(1-methyl-1H-pyrazol-4-yl)-1-oxo-2,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide Catalog No. CSN17165
Synonyms: PF 00477736;PF-736
PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes and shows ~100-fold selectivity for Chk1 than Chk2.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00437203 Neoplasms Phase 1 Terminated(See termination rea... more >>son in detailed description.) Collapse << - United States, California ... more >> Pfizer Investigational Site Los Angeles, California, United States, 90095-6984 Pfizer Investigational Site Los Angeles, California, United States, 90095 Pfizer Investigational Site Santa Monica, California, United States, 90403 Pfizer Investigational Site Santa Monica, California, United States, 90404 United States, New York Pfizer Investigational Site New York, New York, United States, 10022 Pfizer Investigational Site New York, New York, United States, 10065 Australia, Victoria Pfizer Investigational Site East Melbourne, Victoria, Australia, 3002 Collapse << NCT00437203 - - Terminated(See termination rea... more >>son in detailed description.) Collapse << - - - 参考文献
- [1] Chakraborty J, Banerjee S, et al. Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute myeloid leukemia cells. J Biol Chem. 2010 Oct 22;285(43):33104-12.
- [2] Blasina A, Hallin J, et al. Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1. Mol Cancer Ther. 2008 Aug;7(8):2394-404.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 952021-60-2 | 储存条件 |
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| 分子式 | C22H25N7O2 | 运输 | 蓝冰 | |||||||||||
| 分子量 | 419.48 | 别名 | PF 00477736;PF-736 | |||||||||||
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动物实验配方 |
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